The gold standard for clinical trials is a randomized trial where some patients receive the active drug while others receive a placebo.
Goals and Objectives
For some trials, it may be possible to substitute preexisting patient data for the placebo. In these cases, all patients would receive the drug, decreasing the trial recruitment burden and improving patient trial satisfaction.
Big data and analytics
Use Case Summary
Where applicable, synthetic control arms (based on relevant pre-existing patient data) can reduce the number of patients required for a trial, while yielding greater insights into drug efficacy and safety.